By H. Arnouk
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Additional info for Advancements in Tumor Immunotherapy, Cancer Vaccines
Harrop R. (2010). Vaccination of Metastatic Renal Cancer Patients with MVA-5T4: A randomized, double blind, placebo-controlled phase III study. Clinical Cancer Research, Vol. 16, No. 22, (November 2010), pp. , (2007). , & Reitsma D. (1999). , & Harrop R. (2009). Vaccination of Renal Cell Cancer Patients with Modified Vaccinia Ankara Delivering the Tumor Antigen 5T4 (TroVax) Alone or Administered in Combination with Interferon-α (IFN-α): A Phase 2 Trial, Journal of Immunotherapy, Vol. 32, No.
2010). Research supports that peptide and protein vaccines may be a viable option for treating castration-resistant prostate cancer. 2 Dendritic cell vaccines Dendritic cells have been identified as having a critical role in the induction of antitumor response as dendritic cells help present tumor-associated antigens to T lymphocytes. Researchers have become interested in dendritic cells because all class I or class II-restricted protein antigens must be processed by dendritic cells in order to activate the body’s immune response (Banchereau, & Steinman, 1998) and to prime and activate CD4+ and CD8+ cells.
2006). Dendritic cell-based multi-epitope immunotherapy of hormone-refractory prostate carcinoma. Cancer Immunolology, Immunotherapy, Vol. 55, No. 12, (December 2006), pp. , & Escudier B. (2008). An adjuvant autologous therapeutic vaccine (HSPPC-96;vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma; a multicentre, open-label, randomized phase III trial, The Lancet, Vol. 372, No. 9633, (July 2008), pp. W. (2009). Intravesical immunotherapy of superficial bladder cancer with chitosan/interleukin-12.
Advancements in Tumor Immunotherapy, Cancer Vaccines by H. Arnouk