Toxicology

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By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

ISBN-10: 1461559375

ISBN-13: 9781461559375

This quantity represents the lawsuits of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which was once held on the Grove Park lodge and hotel in Asheville, North Carolina, October 13-17, 1996. we're thrilled to offer this quantity to the ophthalmic neighborhood, specially people with an important curiosity in ocular toxicol­ ogy. The 5th Congress used to be constructed round issues with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt concerns with regards to using substitute equipment for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to diversified animal versions. the result of this congress, embodied during this quantity, is a contribution to the methodologies presently hired or lower than improvement and to numerous drug or actual results on various ocular tissues. whereas the focal point of this lawsuits is on ocular results of gear or different fabrics, a few of the contributions care for themes that experience a much wider curiosity. The workshop in regards to the use of alternative version platforms and the alternative of the easiest animal version for drug trying out covers a variety of pursuits that ex­ has a tendency a ways past particular ocular results. this can be very true within the sector of different equipment and within the selection of the simplest animal version for exam of alternative sickness entities.

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Corneal endothelial cytoskeletal changes in Factin with aging, diabetes, and after cytochalasin exposure. Am J Ophthalmol 1992; 114:329-335. 3 PROTEIN-THIOL MIXED DISULFIDES AND THIOLTRANSFERASE IN THE LENS A Review Marjorie F. Lou Center for Biotechnology Department of Veterinary and Biomedical Sciences University of Nebraska-Lincoln Lincoln, Nebraska 68583 and Department of Ophthalmology University of Nebraska Medical Center Omaha, Nebraska 68198 ABSTRACT Oxidative stress is considered an important factor in human senile cataract formation, in fact many consider it as the primary mechanism that is responsible for cataracts.

Individual lens PSSG level (measured as GS03 H) is expressed as Ilmol g" wet weight. Linear regression line for data between zero and 19 years. 05. :, a aS €l 3 a 00 a a '-' 00 a a a 2 a oar§! a cB a :r: Vl a aBC{) a 0 00 1 0 10 20 30 40 50 60 AGE (years) 70 80 90 Figure 5. Free GSH levels in normal human lenses as a function of age. 0005. yrs may be associated with a physiological function of PSSG in the lens while the latestage elevation is mostly pathological. It is also speculated that an age-dependent decrease in free GSH, in particular in older lenses, may contribute to the accumulation of PSSG in the same lenses (Figure 5).

A aS €l 3 a 00 a a '-' 00 a a a 2 a oar§! a cB a :r: Vl a aBC{) a 0 00 1 0 10 20 30 40 50 60 AGE (years) 70 80 90 Figure 5. Free GSH levels in normal human lenses as a function of age. 0005. yrs may be associated with a physiological function of PSSG in the lens while the latestage elevation is mostly pathological. It is also speculated that an age-dependent decrease in free GSH, in particular in older lenses, may contribute to the accumulation of PSSG in the same lenses (Figure 5). The effect of age on PSSG and PSSC in cortical and nuclear regions of the lens and the WS and WI protein fractions are summarized in Tables 4 and 5 respectively.

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Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)


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